Accelera has the know-how and experience to develop, assess and validate population PK and PK/PD models through:
- analysis planning (study and sampling design)
- dataset construction (e.g. handling outliers and missing data)
- base model building
- covariates analysis
- model validation
- parameter estimation
- predictions
- sensitivity analysis and parameter stability.
- PD and PK/PD for supporting pharmacology studies and clinical development.
- Parametric and non-parametric PD and PK/PD models, using novel mathematical-statistical approaches such as non-linear and non-linear mixed modeling techniques, for estimating drug potency.
- Simulation of different scenarios for optimizing preclinical and clinical experimental designs.
- Software development for specific data analysis (PK, PD, PK/PD modelling and application of population approaches).
