Small Molecules

Accelera offers a full range of bioanalytical and pharmacokinetic services to support the development of new chemical entities.

Equipment
  • 20+ state-of-the-art LC-MS/MS systems, including API 5000, API QTrap, QTOF, API 5500 (New!), Orbitrap (New!)
  • High capacity automated systems for sample handling on multiple 96-well plates
  • Watson validated LIMS system, 21 CFR part 11 compliant
  • Spylog for continuous temperature monitoring of -20 °C and -80 °C sample storage.
Services
  • Fast method development for discovery compounds
  • Method Development and Validation for GLP TK studies and clinical trials
  • Rapid turnaround for Phase I Clinical Studies
  • Bioanalytical and PK support to Phase II-III clinical studies
  • PK data analysis, including population PK and PK/PD modelling, using validated software systems (e.g. Winnonlin, NONMEM)
  • Logistical support for clinical sample management (sampling kits, labels, investigator manual, etc.)
  • Synthesis of isotopically labelled internal standards, parent compounds and metabolites (2H, 13C, 15N, 18O)
  • Metabolite profiling and identification in preclinical and clinical samples.