Drug Disposition

Working hand in hand with our Isotope Chemistry team, Accelera have the capability to evaluate tissue distribution of drug candidates and to estimate excretion of radiolabeled compounds in all animal species:
  • Excretion balance and metabolism studies in multiple animal species
  • Quantitative Whole Body Autoradiography (QWBA) in rodents and non-human primates
  • Hepatic clearance/bile studies
  • In vitro/in vivo dermal absorption
  • Cross species plasma protein binding (equilibrium dialysis, ultrafiltration, ultracentrifugation), using both radiolabelled and unlabelled items.