Isotope Chemistry & Drug Disposition
Accelera offers a full range of Isotope Chemistry services of radiolabelled and stable labelled compounds for GLP preclinical studies. Labelled compounds can be prepared, formulated and analyzed according to customers specifications, published procedures, or using methods developed from scratch.
Isotope Chemistry services include:
Consultancy on most convenient isotope and labelling position
Custom synthesis of compounds labelled with stable and radioactive isotopes
Labeling of different classes of compounds, including polymers, volatile compounds, natural compounds, peptides etc.
Most commonly used radioactive (e.g. 14C, 3H, 35S, 125I etc.) and stable isotopes available (e.g. 13C, 2H, 18O, 15N etc.)
Synthesis of radiolabelled compounds with high specific activity for binding studies
Synthesis of stable labelled internal standards (SLIS) (Parent compound and metabolites)
Synthesis of non-labelled metabolites
Rapid purification by low-pressure liquid chromatography (automated Flashmaster and Biotage) and preparative HPLC
Formulation of labelled compounds for non-regulated as well as for GLP studies
Analyses of stable and radiolabelled compound
Certificate of analyses of labeled compounds
Drug disposition
Working hand in hand with our Isotope Chemistry team, Accelera have the capability to evaluate tissue distribution of drug candidates and to estimate excretion of radiolabeled compounds in all animal species:
Excretion balance and metabolism studies in multiple animal species
Quantitative Whole Body Autoradiography (QWBA) in rodents and non-human primates
Hepatic clearance/bile studies
In vitro/in vivo dermal absorption
Cross species plasma protein binding (equilibrium dialysis, ultrafiltration, ultracentrifugation), using both radiolabelled and unlabelled items
Other Services
General Toxicology
General Toxicology
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