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Isotope Chemistry & Drug Disposition

 

Accelera offers a full range of Isotope Chemistry services of radiolabelled and stable labelled compounds for GLP preclinical studies. Labelled compounds can be prepared, formulated and analyzed according to customers specifications, published procedures, or using methods developed from scratch.

 Isotope Chemistry services include:

  Consultancy on most convenient isotope and labelling position

  Custom synthesis of compounds labelled with stable and radioactive isotopes

  Labeling of different classes of compounds, including polymers, volatile compounds, natural compounds, peptides etc.

  Most commonly used radioactive (e.g. 14C, 3H, 35S, 125I etc.) and stable isotopes available (e.g. 13C, 2H, 18O, 15N etc.)

  Synthesis of radiolabelled compounds with high specific activity for binding studies

  Synthesis of stable labelled internal standards (SLIS) (Parent compound and metabolites)

  Synthesis of non-labelled metabolites

  Rapid purification by low-pressure liquid chromatography (automated Flashmaster and Biotage) and preparative HPLC

  Formulation of labelled compounds for non-regulated as well as for GLP studies

  Analyses of stable and radiolabelled compound

  Certificate of analyses of labeled compounds

 Drug disposition

Working hand in hand with our Isotope Chemistry team, Accelera have the capability to evaluate tissue distribution of drug candidates and to estimate excretion of radiolabeled compounds in all animal species:

  Excretion balance and metabolism studies in multiple animal species

  Quantitative Whole Body Autoradiography (QWBA) in rodents and non-human primates

  Hepatic clearance/bile studies

  In vitro/in vivo dermal absorption

  Cross species plasma protein binding (equilibrium dialysis, ultrafiltration, ultracentrifugation), using both radiolabelled and unlabelled items

Other Services

General Toxicology

Reproductive Toxicology
Safety Pharmacology
Bioanalytical Services
Regulatory Services

General Toxicology

Reproductive Toxicology
Safety Pharmacology
Bioanalytical Services
Regulatory Services

 Need information?

Please contact us if you would like to arrange a visit to your company by one of our representatives, to request a proposal, or for any more information on our services.

info@accelera.org

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