Accelera provides a full service in Developmental and Reproductive Toxicology (DART) for the progression of pharmaceuticals and biopharmaceuticals.
We conduct male and female fertility developmental toxicity and pre/postnatal development (PPND) studies to assess the potential effects of a test article on the full spectrum of reproduction as well as performing a range of specialised functional evaluations, including neurobehavioral testing and immunologic assays.
In Vivo (ICH compliant – GLP regulated)
Accelera also offers a full regulated in vivo toxicological package, with studies conducted via different routes of administration, including TK evaluation in adult animals and pups:
Fertily study in male and female (DRF and main studies – species: rat, mouse)
Embryofetal developmental toxicity study (DRF and main studies – species: rat, mouse, rabbit)
Pre- and postnatal developmental toxicity study (DRF and main studies – species: rat, mouse)
Juvenile studies (designed ad hoc) – rat, mouse
In vitro DART (non-GLP)
Accelera offers Rat Whole Embryo Culture as an in vitro models to perform a rapid and affordable insight into teratogenic potential of new compounds or to investigate mechanisms of teratogenicity to improve extrapolation of animal data to humans.